Crewe Alexandra can now confirm their full pre-season fixture list for the 2021/22 campaign.
| Nantwich Town (A) | Sunday 11 July | 12pm KO |
| Witton Albion (A) | Wednesday 14 July | 7:45pm KO |
| Ashton United (A) | Wednesday 14 July | 7:45pm KO |
| Wolverhampton Wanderers (H) | Saturday 17 July | 3pm KO |
| Ashton Hulme Charity Match - Stoke City (H) | Tuesday 20 July | 7pm KO |
| Kidsgrove Athletic (A) | Wednesday 21 July | 7:30pm KO |
| Nottingham Forest (H) | Saturday 24 July | 3pm KO |
| Oldham Athletic A.F.C (A) | Tuesday 27 July | 7pm KO |
| Wolverhampton Wanderers U23s (A) | Wednesday 28 July | 2pm KO |
| Huddersfield Town (A) | Saturday 31 July | 12:30pm KO (Behind-Closed-Doors) |